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KMID : 1164620200530040160
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Korean Journal of Thoracic and Cardiovascular Surgery
2020 Volume.53 No. 4 p.160 ~ p.167
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The Current Evidence on Neoadjuvant Therapy for Locally Advanced Esophageal Squamous Cell Carcinoma
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Oh Dong-Ryul
Kim Jong-Hoon
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Abstract
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Surgical resection is the mainstay of treatment for locally advanced esophageal cancer. Neoadjuvant therapy is recommended to improve survival, based on the results of several randomized trials and meta-analyses. However, controversy remains regarding how to combine surgery, radiotherapy, and chemotherapy. Moreover, in East Asia, the predominant histological type is esophageal squamous cell carcinoma, which has a different epidemiology and tumor biology from esophageal or gastroesophageal junctional adenocarcinoma. As such, the management of esophageal cancer in East Asia seems to be different from that in Western countries. Thus, this article reviews the current evidence on neoadjuvant therapy and considers the optimal combinations and ongoing strategies of multimodal therapy for esophageal squamous cell carcinoma.
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KEYWORD
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Esophageal neoplasms, Squamous cell carcinoma, Neoadjuvant therapy, Chemotherapy, Chemoradiotherapy
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