KMID : 1188320150090060805
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Gut and Liver 2015 Volume.9 No. 6 p.805 ~ p.808
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Successful Xenograft of Endoscopic Ultrasound-Guided Fine-Needle Aspiration Specimen from Human Extrahepatic Cholangiocarcinoma into an Immunodeficient Mouse
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Jang Se-Young
Bae Han-Ik Lee In-Kyu Park Hwan-Ki Cho Chang-Min
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Abstract
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Patient-derived tumor xenograft is the transfer of primary human tumors directly into an immunodeficient mouse. Patient-derived tumor xenograft plays an important role in the development and evaluation of new chemotherapeutic agents. We succeeded in generating a patient-derived tumor xenograft of a biliary tumor obtained by endoscopic ultrasound-guided fine-needle aspiration from a patient who had an inoperable extrahepatic cholangiocarcinoma. This patient-derived tumor xenograft will be a promising tool for individualized cancer therapy and can be used in developing new chemotherapeutic agents for the treatment of biliary cancer in the future.
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KEYWORD
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Cholangiocarcinoma, Endoscopic ultrasound-guided fine needle aspiration, Individualized medicine, Xenograft
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