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KMID : 1188520050010010082
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Korean Journal of Clinical Oncology
2005 Volume.1 No. 1 p.82 ~ p.91
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Systemic overview of 5-FU based chemotherapy in stomach cancer
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Lee Jong-Inn
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Abstract
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The fluoropyrimidine 5-fluorouracil(5-FU) which was synthesized by Dr. Charles Heidelberger in 1957 exert sits cytotoxic effects by inhibition DNA synthesis through interfering thymydylate synthase and interferences with function and processing of RNA. 5-FU has broad spectrum of action against gastrointestinal malignancies(esophageal, gastric, pancreatic, colorectal, anal and hepatocellular cancers), breast cancer, head and neck cancer, and ovarian cancer. It is used as a single therapy and also used as a key drug of multiple combination therapy. Application of 5-FU to gastric cancer follows as the history of chemotherapy of gastric cancer. Oral 5-FU drugs were introduced for compensation of difficulties of intravenous administration, however, they have demerits of various bioavailability. Novel oral 5-FU drugs recovered these demerits and were reported as they have nearly same cytotoxicity as continuous infusion of 5-FU. In this article, general concepts of chemotherapy, chemotherapeutic agents and chemotherapy against gastric cancer including 5-FU were reviewed.
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KEYWORD
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Gastric Cancer, Chemotherapy, 5-FU
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