|
KMID : 1188520090050010015
|
|
Korean Journal of Clinical Oncology
2009 Volume.5 No. 1 p.15 ~ p.20
|
|
|
Clinicopathologic Characteristics of HER-2/neu Overexpressing Breast Cancer
|
|
Kim Chul-Nam
|
|
|
Abstract
|
|
|
Purpose : Clinicopathologic factors associated with prognosis in breast cancer patients have varied. HER-2/neu gene amplification and/or protein overexpression occur in 14-30% of all cases of breast cancer. Among clinicopathologic factors, HER-2/neu gene status has been suggested to be a significant prognostic indicator for breast cancer. The objective of this study was to determine whether HER-2/neu gene expression is associated with other clinicopathologic factors in breast cancer.
Methods : The expression of HER-2/neu, Ki-67, p53, estrogen receptor and progesterone receptor was determined immunohistochemically and medical records were reviewed in 119 breast cancer patients, including 87 patients that demonstrated the absent of HER-2/neu expression and 32 patients with the present of HER-2/neu expression.
Results : HER-2/neu expression was noted in 32 patients (26.9%) of the 119 breast cancer patients. Of the 87 patients(73.1%) with absent of HER-2/neu expression. There was a significant correlation between HER-2/neu expression and the nodal status (p=0.023), lymphovascular invasion(p=0.029), histologic grade(p=0.041), nuclear grade(p=0.001), estrogen receptor status(p=0.001) and progesterone receptor status(p=0.004). Nuclear grade was statistically significant association factor with HER-2/neu expression status independently in multivariate analysis.(p=0.041, relative risk 0.177, 95% CI 0.043-0.733)
Conclusion : This study demonstrates the potential value of the lymph nodal status, lymphovascular invasion, histologic grade, nuclear grade and hormonal receptor status correlating with the status of HER-2/neu expression in human breast cancer.
|
|
|
KEYWORD
|
|
|
HER2/neu, Clinicopathologic feature, Breast cancer
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|