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KMID : 1188520090050020020
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Korean Journal of Clinical Oncology
2009 Volume.5 No. 2 p.20 ~ p.24
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Reviewing of cancer stem cell hypothesis
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Hur Min-Hee
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Abstract
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Recent results have supported the cancer stem cells hypothesis in which tumors originate from tissue stem cells or their
early progenitors and, as a result, produce tumors that retain stem cell properties. These properties drive tumorigenesis
and differentiation that contributes to cellular heterogeneity. In breast cancers, a cell population of surface marker
CD44+CD24-or low is highly tumorigenic. Aldehyde dehydronase(ALDH) positive cells are also powerfully tumorigenic and this marker can be poor prognostic factor in breast cancer patients. The number of cancer stem cells is very small, and is
tightly controlled by the self-renewal pathway and the signals of their environment (niche). Epithelial-mesenchymal
transition(EMT) is a key development program that is often activated during cancer invasion and metastasis. Although our
understanding of the biology of these cancer stem cells remains rudimentary, the existence of these cells has implications
for current conceptualization of malignant transformation and the treatment of cancer.
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KEYWORD
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cancer stem cells, CD44(+)CD24(-or Low), ALDH, EMT
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