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KMID : 1188520100060010040
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Korean Journal of Clinical Oncology
2010 Volume.6 No. 1 p.40 ~ p.46
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Clinical significance of tumor size in Gastric cancer
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Kim Hak-Jin
Jang You-Jin
Kim Jong-Han
Park Sung-Soo
Park Sung-Heum
Kim Seung-Joo
Mok Young-Jae
Kim Chong-Suk
Park Jung-Min
Yang Kyung-Sook
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Abstract
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Purpose: The objectives of this study were to investigate the impact of the tumor size on survival of gastric cancer patients who underwent curative resection and to evaluate relationships between tumor size and lymph node metastasis
Materials and Methods: We retrospectively studied 928 gastric cancer patients who underwent curative resection at Korea University Medical Center from 1992 to 2002. The cut-off value of tumor size was decied as the smallest value that showed significantly survival difference by COX proportional hazard model. The clinicopathological factors associated with tumor size were analyzed by using univatiate and multivariate analyses. And ROC curves were applied to measure cut-off value of tumor size that impact on lymph node metastasis.
Results: In COX proportional hazard model , the cut-off value of tumor size was 7cm that impact on prognosis. The tumor location, depth of invasion, lymph node metastasis, and cell differenciation were significantly different according to the tumor size. The Age, depth of invasion, tumor size and lymph node metastasis were independent prognostic factors by using multivariate analyses. In Releavance between the tumor size and lymph node metastasis, there were significant difference stage I, III, and whole patients group. And the each cut-off values were 1.5cm, 6cm, and 3.3cm
Conclusion:Tumor size was significant prognostic factor and important predictive value for lymph node metastasis in gastric cancer. So tumor size will useful parameter to perform EMR in early gastric cancer or to plan further management of advanced gastric cancer.
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KEYWORD
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Gastric cancer, tumor size, Lymph node metastasis, Clinical significance
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