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KMID : 1188520110070020012
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Korean Journal of Clinical Oncology
2011 Volume.7 No. 2 p.12 ~ p.21
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Are there the specific prognostic factors for triple-negative subtype of early breast cancers (pT1-2N0M0)?
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You Ji-Young
Lee Hye-Yoon
Lee Eun-Sook
Bae Jeoung-Won
Woo Sang-Uk
Park Kyong-hwa
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Abstract
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Purpose: Triple-negative breast cancer typically results in poorer prognoses compared to non-triple negative breast cancer, even in early stages. The initial management of triple negative breast cancer patients and detection of clear prognostic factors are therefore of great importance. We aimed to identify specific prognostic factors associated with unfavorable outcomes of triple negative breast cancer in T1-2 node-negative breast cancer.
Materials and Methods: We analyzed breast cancer patients without lymph node metastasis or distant metastasis who underwent curative surgery at the Anam Hospital of the Korea University Medical Center between 1995 and 2006. Among them, patients were eligible for analysis, only if the reports about hormone receptor and human epidermal growth factor receptor-2 status were available. Clinico-pathological features were reviewed by retrospective examination and comparison of medical records of triple negative breast cancer and non-triple negative breast cancer patients.
Results: Seventy-nine patients (22.9%) were categorized to the triple negative breast cancer group. The diseasefree survival rate of TNBC p53-positive patients was significantly lower than that of p53-negative patients (p=0.028). In multivariate analysis, young age was an independent prognostic factor for disease-free survival of the triple negative breast cancer group. High Ki-67 expression was a significant prognostic factor in univariate analysis in triple negative breast cancer, but it was not significant in multivariate analysis.
Conclusion: We suggest that age is an independent prognostic factor of triple negative breast cancer in T1-2 and node-negative patients and that Ki-67 could also be a prognostic factor in these patients.
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KEYWORD
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triple negative breast cancer, lymph node negative, p53, Ki-67, young age
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