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KMID : 1188520110070020050
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Korean Journal of Clinical Oncology
2011 Volume.7 No. 2 p.50 ~ p.57
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The Relationship between the progression of colorectal cancer and microRNA polymorphisms
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Jang Ho-Jin
Kim Jong-Woo
Kim Nam-Keun
Jeon Young-Joo
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Abstract
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Purpose: MicroRNA(miRNA) is related not only with basic biologic process but with regulatory functions of diverse diseases including cancer. Although it is non-coding RNA of small nucleotides(18~23), nucleotide variation within primary(pri)- or precursor(pre)-miRNA might affect the mature process of miRNA and can cange it. And then we aim to elucidate the relationship between 4 kinds of pre-miRNA and clinical progress of colorectal cancer such as tumor stage, depth of invasion and regional lymph nodes metastasis.
Methods: DNA was extracted from blood samples of 160 patients who underwent operation on colorectal cancers during recent 2 years and has-mir-146aC＞G, has-mir-149T＞C, has-mir-196a2T＞C and has-mir-499A＞G polymorphisams were genotyped by PCR-RFLP.
Results: There was no relationship between the polymorphism distributions of 4 kinds of pre-miRNA and any clinical progresses of colorectal cancer.
Conclusion: Although we were unable to find out significant relation between two categories, further active studies with miRNAs and cancers shoud be carried on.
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KEYWORD
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MicroRNA, polymorphism, Colorectal cancer
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