|
KMID : 1188520120080020030
|
|
Korean Journal of Clinical Oncology
2012 Volume.8 No. 2 p.30 ~ p.36
|
|
|
Results of pre-operative chemotherapy for breast cancer in single institute and Ultrasound mesurements in pathologic response
|
|
Lee Moon-Il
Cho Young-Up
Kim Sei-Joong
Kim Youn-Jeong
|
|
|
Abstract
|
|
|
Purpose : The objective of this study was to evaluate pre-operative chemotherapy of efficacy for breast cancer and re-assessment of breast U/S as modality to test response rate. It was to review correlations the findings of ultrasonography(US) and magnetic resonance (MR) imaging in patients.
Methods : retrospective review identified Ninety-three patients who underwent pre-operative chemotherapy between July, 1996 and December, 2004 were included for this study. We analysed the response rate to adjuvant chemotherapy by reviewing the post operative pathologic report. All patients was performed US after preoperative chemotherapy, and 26 (27.9%) patients was performed both US and MRI to compare pre-operation tumor size by U/S and MRI with the post operative pathologic report’s tumor sizes. Statistical analyses were performed with 2-tests and using SPSS 13.0.
Results : The mean age at diagnosis was 46.98(22-74) yrs old. Pre-operation clinical stage was 4 patients for stageⅠ, 40 patients for stage Ⅱ, 47 patients for stage Ⅲ and 2 patients for stage Ⅳ 2. And the tumoral response to preoperative chemotherapy as, 7 patients showed a complete response (CR), 52 patients showed a partial response (PR), 24 patients showed a stable disease (SD), and 10 patients showed a progressive disease(PD). Each 5 years overall survival rate was 85.8%, 92.3%, 95.8%, 90.0%. The correlation coefficient (r) of US to pathological tumor size was 0.910 in all tumors, The correlation coefficient (r) of MRI to pathological tumor size was 0.860 in all tumors. (P<0.05).
Conclusions : This study results were similar to other published current studies for neoadjuvant chemotherapy for breast cancer. The correlation between tumor size in U/S and pathological tumor size corresponded best. So it doesn’t need to performed MRI for all patients to evaluate response rate. Breast U/S considered as optional modality to evaluate response.
|
|
|
KEYWORD
|
|
|
Breast cancer, Pre-operative chemotherapy, Response rate, Breast U/S, MRI
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|