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KMID : 1188520120080020044
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Korean Journal of Clinical Oncology
2012 Volume.8 No. 2 p.44 ~ p.49
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Diagnostic Value of Positron Emission Tomography-Computed Tomography (PET/CT) in Detection of Recurrence after Curative resection for Colorectal Cancer
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Hong Young-Ki
Kim Woo-Ram
Choi Yoon-Jung
Kang Jung-Koo
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Abstract
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Introduction : Accurate detection of recurrent colorectal cancer remains a diagnostic challenge. The purposes of this study were to evaluate the diagnostic value of Positron Emission Tomography-Computed Tomography (PET/CT) using flour-18-deoxyglucose (FDG) in Detection of Recurrence after Curative resection for Colorectal Cancer.
Material and Methods : We performed a retrospective review of 248 patients who underwent PET/CT for surveillance of colorectal cancer after curative resection between June 2008 and April 2011. Recurrence of colorectal cancer was validated by histopathologic examination or serial imaging study follow-up.
Results : Of the 248 patients (149 males) included in the study, thirty-six patients (14.5%) were confirmed as recurrence. Liver was the most common site of recurrence (n=13). A total 472 PET/CT were conducted in 248 patients during follow-up period. The sensitivity and specificity of PET/CT were 0.921(95% Cl 0.908-0.934) and 0.981(95% Cl 0.975-0.987) for detecting tumor recurrence. The sensitivity and specificity of contrast enhanced computed tomography (CECT) were 0.902(95% Cl 0.888-0.916) and 0.952(95% Cl 0.942-0.952). CEA elevation was shown in only 13 cases (36.1%) of patients with recurrence. The treatment plans of 26 cases (10.5%) were altered by PET/CT findings. The curative surgical tumor resection procedure was performed in 15 out of 36 patients. In 3 cases which CECT showed negative findings, PET/CT had detected unexpected metachronous cancer (one colon, two bladders).
Conclusions : Additional PET/CT on CECT seems to provide high detection rate of tumor recurrence after curative resection for colorectal cancer and other critical information such as unexpected secondary malignancy.
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KEYWORD
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Colorectal cancer, Recurrence, PET/CT
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