|
KMID : 1188520120080020062
|
|
Korean Journal of Clinical Oncology
2012 Volume.8 No. 2 p.62 ~ p.69
|
|
|
Expression of epidermal growth factor receptor (EGFR) in phyllodes tumor
|
|
Kim Ji-Young
Kim Ra-Mi
Hong Woo-Sung
Yim Hyun-Ee
Kim Tae-Hee
Kang Doo-Kyoung
Jung Yong-Sik
Kim Ku-Sang
|
|
|
Abstract
|
|
|
Background : Phyllodes tumorof the breast is a rare stromal-epithelial neoplasm with the potential for invasion and metastatic spread, but the clinical behavior of phyllodes tumor is difficult to predict. Specific parameters that define recurrence and prognosis are not universally estabilished yet. We aim to reveal the relationship of EGFR espression and type of phyllodes tumor.
Methods : The study investigated 82 phyllodes tumors (57 benign, 11 borderline, 14 malignant) for EGFR expression using immunohistochemistry (IHC). The staining was correlated to tumor margin status, degree of malignancy, stromal cellularity, mitotic activity, nuclear pleomorphism and stromal overgrowth.
Results : There was an increasing trend of stromal EGFR staining with increasing degree of malignancy (p=0.001 between benign and borderline tumors, p=0.021 between borderline and malignant tumors, p<0.001 between benign and malignant tumors).
Conclusion : We believe that our findings show that EGFR expression and histological parameters can be used for evaluation of breast phyllodes tumors.
|
|
|
KEYWORD
|
|
|
EGFR, Phyllodes tumor, Breast
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|