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KMID : 1188520140100020078
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Korean Journal of Clinical Oncology
2014 Volume.10 No. 2 p.78 ~ p.83
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Expression and clinical significance of the securin in colorectal cancer
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Choi Jae-Hee
Ahn Tae-Sung
Jeong Dong-Jun
Kim Hyung-Ju
Park So-Young
Shin Eung-Jin
Chung Ji-Won
Lee Moon-Soo
Baek Moo-Jun
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Abstract
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Purpose: Securin is a regulatory protein, which plays a central role in chromosome stability and control of the metaphase-anaphase transition and anaphase onset. Securin blocks separase/extra spindle pole bodies homolog 1 function, preventing the proteolysis of the subsequent dissociation of the chromosome. Securin is expressed at low level in most tissues, but many patient suffering epithelial neoplasms are over-expressed. The aim our study was to evaluate whether securin affects tumorigenesis and prognosis in patients of colorectal cancer.
Methods: To clarify the roles of securin in colorectal tumorigenesis, its expression was examined by immunohistochemistry on a tissue microarray with its comparison with clinicopathologic parameters and prognosis survivals of the colorectal carcinomas.
Results: Securin was overexpressedin 272 (76.2%) of 357 colorectal carcinomas. Overexpression of securin was correlated with gender (P=0.060), pathologic T stage (P=0.006) and tumor node metastasis stage (P=0.002), but securin overexpression was not correlated with lymphovascular invasions. Securin overexpression was not correlated with 5-year survival rate by Kaplan-Miere survival model.
Conclusion: Securin expression was correlated with T stage and TNM (tumor node and metastasis) stage in colorectal cancer. Our study showed a possible role for securin in colorectal tumorigenesis. These findings indicate that securin has a function of tumorigenesis with tumor enlargement, not of lymphovasculogenesis.
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KEYWORD
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Carcinogenesis, Chromosomal instability, Colorectal neoplasms, Pituitary tumor-transforming gene protein
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