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KMID : 1188520150110010033
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Korean Journal of Clinical Oncology
2015 Volume.11 No. 1 p.33 ~ p.36
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Primary hepatic choriocarcinoma in a female patient
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Malikov Makhmud
Shin Eun
Cho Jai-Young
Han Ho-Seong
Yoon Yoo-Seok
Choi Young-Rok
Jang Jae-Yool
Choi Han-Lim
Jang Jae-Seong
Kwon Seong-Uk
Kim Hae-Ryoung
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Abstract
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Choriocarcinoma is a germ cell tumor belonging to the spectrum of gestational trophoblastic diseases, and occurs most commonly in the gonads. Primary hepatic choriocarcinoma is very rare, especially in females. A 59-year-old woman was referred to our clinic with a history of upper right quadrant pain lasting 1 month. Computed tomography and magnetic resonance imaging revealed a large hypervascular mass in the right liver, characteristic of angiosarcoma. The patient underwent right hemihepatectomy without unexpected events. Histopathology revealed the tumor as a choriocarcinoma, with numerous syncytiotrophoblasts. Immunohistochemistry was positive for β-human chorionic gonadotropin and CK-19, with a Ki-67 labeling index of 90%. The tumor showed focal positivity for CD31 and human placental lactogen. The patient started chemotherapy (vincristine and cyclophosphamide) on postoperative day 16. The patient’s clinical condition improved and she was discharged on postoperative day 17. Primary hepatic choriocarcinoma in female adults is a rare aggressive tumor, and further studies are needed to improve its diagnosis and treatment.
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KEYWORD
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Hepatic choriocarcinoma, Choriocarcinoma, hepatic
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