|
KMID : 1188520150110020059
|
|
Korean Journal of Clinical Oncology
2015 Volume.11 No. 2 p.59 ~ p.66
|
|
|
Clinical relationship and the prognostic factor between serum carcinoembryonic antigen (CEA) and tissue CEA in colorectal cancer patients
|
|
Choi Dong-Hwan
Shin Dong-Hoon
Park Byung-Soo
Son Gyung-Mo
|
|
|
Abstract
|
|
|
Purpose: The aim of this study was to investigate the prognostic factor for elevating serum carcinoembryonic antigen (CEA) in patients with colorectal cancer and to identify clinical usefulness of tissue CEA.
Methods: Two hundred and eighty-five patients with colorectal cancer were performed serum CEA tests before and after surgery. Also resected tumors were checked expressions pattern of tissue CEA. Clinicopathologic factors were classified according to patient factors, tumor factors and molecular factors. Patient factors included age, sex, underlying liver disease, smoking history and other cancer history. Tumor factors included tumor size, intestinal obstruction, pathologic T status, lymph node metastasis, tumor differentiation, lymphatic invasion, vascular invasion, perineural invasion.
Results: Serum CEA level was markedly elevated in the cytoplasmic pattern of tissue CEA compared to membranous pattern of tissue CEA. As cancer stage progressed, serum CEA level was elevated, which was confined to cytoplasmic pattern of tissue CEA. Independent factors for the elevation of serum CEA by multivariate analysis included tumor size ( ≥ 5 cm) (P = 0.042), complete intestinal Obstruction (P = 0.023) and serum CA 19-9 ( ≥ 37 U/mL) (P = 0.027). p53 overexpression ( ≥ 10%) was related to cytoplasmic pattern in tissue CEA (P = 0.005).
Conclusion: The tumor size and bowel obstruction are considered the main factors, which cause the leakage of intracellular CEA. And membranous patterns of tissue CEA can be used in Stage I colorectal cancer patients, as an indicator for early prognosis and recurrence. However, more studies of colorectal population are required for further evaluation.
|
|
|
KEYWORD
|
|
|
Colorectal cancer, Serum CEA, Tissue CEA
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|