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KMID : 1188520170130010025
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Korean Journal of Clinical Oncology
2017 Volume.13 No. 1 p.25 ~ p.31
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Human epidermal growth factor receptor 2 expression in gastric cancer patients treated with curative intent gastrectomy
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Kim Min-Kyu
Lee Sang-Eok
Sohn Jang-Sihn
Choi In-Seok
Moon Ju-Ik
Yoon Dae-Sung
Chun Ki-Won
Lee Hye-Yoon
Sung Nak-Song
Park Si-Min
Choi Won-Jun
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Abstract
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Purpose: This study aimed to clarify the association between human epidermal growth factor receptor 2 (HER-2) status and the clinicopathologic factors of patients who underwent curative intent gastrectomy.
Methods: From June 2011 to May 2015, curative intent gastrectomy was performed in 441 patients at Konyang University Hospital. Among them, we evaluated the HER-2 status in 113 patients. Data on clinicopathologic parameters such as age, sex, histological subtype, endoscopic Lauren classification, tumor location, size, presence of lymphovascular invasion, invasion depth, pathologic stage, HER-2 overexpression, recurrence and survival were obtained. In this study, pathological HER-2 intensity scores of 0, 1+, and 2+ were assumed to be negative, 3+ only was to be positive for overexpression.
Results: In a total of 113 cases who underwent curative intent gastrectomy with HER-2 testing, 16 (14.2%) cases had positivity of HER-2 overexpression. HER-2 overexpression had significant associations with tumor stage (19.0% in I-IIIb vs. 2.9% in IIIc-IV, P=0.036). Survival analysis of HER2 overexpression has no significant difference.
Conclusion: In this study, HER-2 overexpression rate was 14.2% and patient tumor stage had significant association with HER-2 overexpression.
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KEYWORD
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HER-2, Gastric cancer
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