KMID : 1188520170130020068
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Korean Journal of Clinical Oncology 2017 Volume.13 No. 2 p.68 ~ p.74
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Carcinoembryonic antigen levels of tumor-draining venous blood as a prognostic marker in colon cancer
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Choi Sun-Hyung
Yang Seung-Yoon Han Yoon-Dae Cho Min-Soo Hur Hyuk Lee Kang-Young Kim Nam-Kyu Min Byung-Soh
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Abstract
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Purpose: Carcinoembryonic antigen (CEA) is a tumor marker for colorectal cancer (CRC) related to recurrence and prognosis. We examined the ability of the CEA level measured directly from a tumor drainage vein (dCEA) to predict the prognosis of CRC more accurately than those from a peripheral vein (pCEA).
Methods: Fifty-two patients who received curative resection for colon adenocarcinoma were enrolled. The patients were categorized into two groups according to normal pCEA (<5.9425 ng/mL, n=24) or elevated pCEA levels (¡Ã5.9425 ng/mL, n=28). Blood was sampled at the time of surgery simultaneously from the tumor drainage vein and from the peripheral vein.
Results: The clinicopathologic variables showed no significant difference between the two groups. Patients with dCEA levels <20.192 ng/mL showed better disease-free (P=0.009) and overall survival (P=0.033) curves than those with dCEA levels ¡Ã20.192 ng/mL. Elevated dCEA levels were a significant prognostic factor for overall survival and disease-free survival in Cox proportional hazard model analysis (hazard ratio [HR]=399; 95% confidence interval [CI], 16.4?9,747; P<0.001; HR=9.39, 95% CI, 1.29?68.006; P=0.026). In subgroup analysis, we compared the data of normal range of dCEA group and elevated dCEA group with normal pCEA; the overall survival rate of patients with normal dCEA was better and the disease-free survival rate was significantly better (P=0.003).
Conclusion: CEA levels from a tumor drainage vein can be used as more accurate prognostic markers than levels from a peripheral vein in patients with colon cancer.
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KEYWORD
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Carcinoembryonic antigen, Prognosis, Colorectal cancer
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