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KMID : 1188520170130020102
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Korean Journal of Clinical Oncology
2017 Volume.13 No. 2 p.102 ~ p.107
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Comparison of post-surgery follow-up methods in patients aged 80 years or older with non-metastatic colorectal cancer
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Seo Dong-Min
Park Ji-Won
Lee Dong-Woon
Kwon Yoon-Hye
Song In-Ho
Ryoo Seung-Bum
Jeong Seung-Yong
Park Kyu-Joo
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Abstract
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Purpose: Studies investigating the appropriate post-surgery follow-up method for elderly patients with colorectal cancer are limited. Thus, the purpose of this study was to compare survival rates between two follow-up methods in patients aged 80 years or older who underwent surgery for colorectal cancer.
Methods: Between January 1, 2002 and December 31, 2010, 165 patients aged 80 years or older underwent curative resection for non-metastatic colorectal cancer at the Department of Surgery, Seoul National University Hospital. Sixty-six of these patients were excluded due to the lack of follow-up, while the remaining 99 were included in our study. These 99 patients were divided into the following two groups depending on their post-surgery follow-up method. Patients who underwent follow-up on a regular basis, which was defined as once every six months to one year, with carcinoembryonic antigen (CEA) and computed tomography (CT) comprised the Regular group, and those who received follow-up with CEA alone or underwent CT procedures once every two years or more comprised the Minimal group. Overall survival was analyzed with the log-rank test and Cox regression analysis.
Results: Of the 99 patients, 62 were in Regular group and 37 were in Minimal group. There was no difference in overall survival rate between the two post-surgery follow-up methods (regular group vs. minimal group: 51.6% vs. 50.9% [5-year overall survival rate], P=0.819). Additionally, no significant differences was detected between the groups following multivariate analysis (harzard ratio=0.907; 95% confidence interval=0.460?1.788, P=0.777).
Conclusion: A significant survival gain was not observed between Regular and Minimal group. To draw a more definite conclusion, a multi-center randomized research study should be conducted.
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KEYWORD
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Surveillance, Carcinoembryonic antigen, Computed tomography, Overall survival, Colorectal cancer
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