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KMID : 1188520220180010027
Korean Journal of Clinical Oncology
2022 Volume.18 No. 1 p.27 ~ p.35
Is a cutoff value of 12 still useful in stage II right-sided colon cancer without risk factors?
Hwang Jin-Seok

Lee Dong-Hyoun
Shin Jung-Kyong
Jang Jae-Hyuck
Huh Jung-Wook
Park Yoon-Ah
Cho Yong-Beom
Kim Hee-Cheol
Yun Seong-Hyeon
Lee Woo-Yong
Chun Ho-Kyung
Abstract
Purpose: Various clinical practice guidelines recommend at least 12 regional lymph nodes should be removed for resected colon cancer. According to a recent study, the lymph node yield (LNY) in colon cancer surgery in the last 20 years has tended to increase from 14.91 to 21.30. However, it is unclear whether these guidelines adequately reflect recent findings on the number of harvested lymph nodes in colon cancer surgery. The aim of this study is to assess the impact of an LNY of more than 25 on survival in right-sided colon cancer.

Methods: We included 285 patients who underwent a right hemicolectomy during the period from January 2010 through December 2015. Patients were divided into two groups (<25 nodes and ¡Ã25 nodes). Primary endpoints included 5-year and 10-year survival including disease-free and overall.

Results: We found that survival outcomes of patients with a harvest of ¡Ã25 nodes were not significantly different compared with a <25 group. Large tumor size (5 cm) is significantly associated with poor 5-year and 10-year overall survival.

Conclusion: Survival outcomes of patients with a harvest of ¡Ã25 nodes were not significantly different compared with the <25 group in stage II colon cancer with no risk.
KEYWORD
Colonic neoplasms, Lymph node yield, Cutoff value, Prognosis, Survival
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