KMID : 1197720150080010021
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´ëÇÑÆÄŲ½¼º´ ¹× ÀÌ»ó¿îµ¿Áúȯ ÇÐȸÁö 2015 Volume.8 No. 1 p.21 ~ p.25
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Apathy and Olfactory Dysfunction in Early Parkinson¡¯s Disease
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Hong Jin-Yong
Sunwoo Mun-Kyung Ham Jee-Hyun Lee Jae-Jung Lee Phil-Hyu Sohn Young-Ho
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Abstract
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Objective: Olfactory and emotional dysfunctions are very common in patients with Parkinson¡¯s disease (PD). Olfaction and emotions share common neuroanatomical substrates. Therefore, in this study, we evaluated the association between olfactory and emotional dysfunctions in patients with PD.
Methods: Parkinson¡¯s disease patients who had been assessed for their olfactory function and neuropsychiatric symptoms including emotional dysfunction were included. A logistic regression analysis was performed to evaluate the association between low olfaction and different neuropsychiatric symptoms.
Results: The patients with low olfaction (cross cultural smell identification test score ¡Â 6) showed a higher prevalence of apathy when compared with those with high olfaction, whereas the frequencies of other neuropsychiatric symptoms were comparable between the two groups. A multivariate logistic regression analysis revealed that the presence of apathy/indifference [odds ratio (OR) = 2.859, p = 0.007], age 70 years or more (OR = 2.281, p = 0.009), and the male gender (OR = 1.916, p = 0.030) were significantly associated with low olfaction.
Conclusions: Our results demonstrate that apathy/indifference is a unique emotional dysfunction associated with olfactory dysfunction in PD. The findings also suggest that PD patients with low olfaction have a high prevalence of apathy.
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KEYWORD
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Apathy, Hyposmia, Parkinson¡¯s disease, Neuropsychiatric, Emotion
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