|
KMID : 1200820000010010064
|
|
Oriental Pharmacy and Experimental Medicine
2000 Volume.1 No. 1 p.64 ~ p.70
|
|
|
Effect of Rhizoma gastrodiae on glucose oxydase induced neurotoxicity in cultured mouse spinal dorsal root ganglion neurons
|
|
Park Seung-Taeck
Park Yang-Kyu
Park Jae-Hwang
Cho Kwang-Ho
Ryu Do-Gon
Jeon Byung-Hoon
Shin Min-Kyo
Han Du-Seok
Cho Nam-Su
Shin Dong-Min
|
|
|
Abstract
|
|
|
|
Effects of Rhizoma gastrodiae on glucose oxidase-induced neurotoxicity was investigated in cultured newborn mouse spinal dorsal root ganglion(DRG) neurons that were treated in the media with or without glucose oxidase. In addition, the protective effect of Rhizoma gastrodiae extract against glucose oxidase-induced neurotoxicity was examined. Cytotoxic values were expressed as a percentage of number of living cells by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. In this paper, exposure of neurons to glucose oxidase resulted in a significant call death in a dose- and time-dependent manners in DRG neuron cultures. The decrease in cell viability induced by the glucose oxidase was blocked by Rhizoma gastrodiae extract. These results indicate that the neuroprotective effect of Rhizoma gastrodiae extract against glucose oxidase-induced neurotoxicity may result from a prevention or attenuation of oxidative damage induced by glucose oxidase.
|
|
|
KEYWORD
|
|
|
Cultured DRG neuron, Oxidative stress, Rhizoma gastrodiae extract
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|