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KMID : 1200820000010020014
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Oriental Pharmacy and Experimental Medicine
2000 Volume.1 No. 2 p.14 ~ p.20
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Effect of dietary Platycodon grandiflorum on plasma glucose and lipid metabolism in mice and streptozotocin-induced diabetic rats
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Seo Eun-Kyung
Kim Kyoung-Sook
Lee Tae-Kyun
Woo Dae-Yoon
Kim Cheorl-Ho
Lee Young-Choon
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Abstract
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This study was designed to investigate the effect of dietary Platycodon grandiflorum on plasma glucose and lipid metabolism in mice and STZ-induced diabetic rats. Both plasma triglyceride and plasma cholesterol levels in STZ-induced diabetic rats were significantly decreased by dietary Platycodon grandiflorum feeding for 4 weeks compared to those of control rats, but there were no marked differences in mice. However, for plasma glucose values, Platycodon grandiflorum feeding resulted in a significant decrease in both STZ-induced diabetic rats and mice. Also, dietary Platycodon grandiflorum slightly decreased the postprandial glucose level at 30 and 60 mins during oral glucose tolerance test in mice. Although there was no statistical significance, the fasting plasma insulin levels of Platycodon grandiflorum dieted mice tended to decrease when compared to that of control mice. Therefore, the present results suggested that dietary Platycodon grandiflorum may have a beneficial effect on preventing hypercholesterolemia and hyperlipidemia.
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KEYWORD
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Platycodon grandiflorum, mice, Streptozotocin-induced diabetic rats, Lipid metabolism
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