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KMID : 1200820000010020029
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Oriental Pharmacy and Experimental Medicine
2000 Volume.1 No. 2 p.29 ~ p.35
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Effect of Salvia plebeia on IgE antibody mediated allergic reaction in rats
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Shin Tae-Yong
Kim Dae-Keun
Choi Young-Kyun
Kim Yong-Jin
Choi Dong-Sung
Kim Sang-Hyun
An Nyeon-Hyung
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Abstract
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The effect of aqueous extract of Salvia plebeia R. Br. (Labiatae) (AESP) on immunoglobulin (lgE) antibody mediated allergic reactions in rats was investigated. AESP inhibited passive cutaneous anaphylaxis (PCA) when intravenously, intraperitoneally, and orally administered. AESP dose-dependently inhibited histamine release from rat peritoneal mast cells activated by anti-DNP IgE antibody. Moreover, AESP had an inhibitory effect on anti-DNP IgE antibody induced production from RPMC. These results suggest that AESP inhibit the IgE-mediated allergic reaction in rats
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KEYWORD
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Salvia plebeia, Allergic reaction, Anti-dinitrophenyl IgE, Mast cells
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