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KMID : 1200820020020010047
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Oriental Pharmacy and Experimental Medicine
2002 Volume.2 No. 1 p.47 ~ p.51
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Inhibitory effect of Se-Yeon-Eum on nicotine- and cigarette smoke extract induced cytotoxicity in human lung fibroblast
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Jin Chong-Shik
Kim Mi-Sun
Lee Eun-Hee
Lee Joon-Ho
Lee Jong-Hyun
Moon Su-Jin
Lee Bo-Ra
Jung Kyung-Phil
Li Hong-Yuan
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Abstract
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There are over 4,000 different chemicals in cigarette smoke, including nicotine and tar. These compounds influence on lung tissue directly or indirectly. In this study, we have examined whether an aqueous extract of Se-Yeon-Eum (SYE), composed of Oriental medicine that has been known to be effective to symptom by smoking, inhibits nicotine- or cigarette smoke extract (CSE)-induced cytotoxicity in human embryonic lung fibroblast, MRC-9. Assessment of cell viability using 3-(4,5-dimethythiazol-2-yl)-2,5-diphenyltetrazolium bromide colorimetric assay indicated that SYE inhibited not only nicotine-induced cytotoxicity but also CSE-induced cytotoxicity. These results suggest the possibility that the use of SYE may be useful for improvement of many symptoms by smoking.
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KEYWORD
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Se-Yeon-Eum, Nicotine, Cigarette smoke extract, Human lung fibroblast, Cytotoxicity
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