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KMID : 1200820020020010052
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Oriental Pharmacy and Experimental Medicine
2002 Volume.2 No. 1 p.52 ~ p.57
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Antitumor evaluation and antimicrobial activity of geranyl phenyl ethers
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Oh Hyun-Ju
Shin Ji-Hee
Chung Woo-Young
Han Du-Seok
Baek Seung-Hwa
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Abstract
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Geranyl phenyl ethers 1, 2, 3, 4 and 5, 5-fluorouracil 6 and adriamycin 7 as references were tested for their growth inhibitory effects against tumor cell lines and NIH 3T3 fibroblasts using two different assays, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) and sulforhodamine B protein (SRB) assays. These results suggest that methyl-4-[{(2E)-3,7-dimethyl-2,6-octadienyl}oxy]-3-methoxy benzoate 1 showed growth inhibition activity against tumor cell lines. The maximum activity exhibited by methyl-4-[{(2E)-3,7-dimethyl-2,6-octadienyl}oxy]-3-hydroxybenzoate 3 against Staphylococcus epidermidis (MIC, ).
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KEYWORD
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Geranyl phenyl ethers, Tumor cell lines, Staphylococcus epidermidis
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