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KMID : 1200820020020010058
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Oriental Pharmacy and Experimental Medicine
2002 Volume.2 No. 1 p.58 ~ p.63
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Effect of Rubus coreanus Miq. fruit extract on compound 48/80-induced anaphylactic reactions
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Kim Suk-Hyun
Lee Kyung-Bo
Choi Yong-Gil
Lee Jae-Kwan
Kim Sung-Hwa
Kim Sang-Hyun
Shin Tae-Yong
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Abstract
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The effect of the aqueous extract of Rubus coreanus Miq. (Rosaceae) fruits (AERC) on anaphylactic reaction was investigated. AERC completely inhibited compound 48/80-induced systemic anaphylactic shock at dose of 0.1 to 1.0 g/kg. When AERC was pretreated at concentrations ranging from 0.01 to 1.0 g/kg, the plasma histamine levels induced by compound 48/80 were reduced in a dose-dependent manner. AERC also inhibited the histamine release from rat peritoneal mast cells (RPMC) by compound 48/80. The level of cAMP in RPMC, when AERC (1.0 mg/ml) was added, transiently and significantly increased about 6-fold compared with that of basal cells. These results indicate that AERC may be beneficial in the treatment of non-specific anaphylactic reactions.
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KEYWORD
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Rubus coreanus, Anaphylaxis, Compound 48/80, Histamine, cAMP
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