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KMID : 1200820020020020094
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Oriental Pharmacy and Experimental Medicine
2002 Volume.2 No. 2 p.94 ~ p.100
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Antifibrotic effects of oriental herbs GLM001 on liver cirrhosis induced by bile duct ligation
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Jeong Bong-Ho
Kim Hee-Seok
Kim Chul
Kim Jae-Sung
Bae Heung-Mo
Kwon In-Sook
Lee Cheol-Han
JeKal Seung-Ju
Yu Byung-Su
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Abstract
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Liver cirrhosis is characterized by hyperaccumulation of fibrous tissue components and is commonly observed in latter or terminal states of chronic hepatic diseases. In this study, the antifibrotic effects of GLM001 on liver cirrhosis were examined in bile duct ligated rats and patients with hepatic diseases. GLM001 (250 mg/kg rat weight/ day) was administrated to cirrhotic rats for 4 weeks and to humans for 14 weeks. Bile duct ligated rats significantly increased liver collagen content and biochemical markers of hepatic injury. Liver histology showed collagen fiber deposition was increased and the normal architecture was lost with large zones of necrosis being observed frequently. GLM001 administrated rats showed significantly decreased liver collagen content, and accumulation of collagen fiber in histological analysis. Patients, who were treated with GLM001, showed decreases in biochemical markers of hepatic diseases. These results demonstrate the usefulness of GLM001 as an antifibrotic agent for liver cirrhosis.
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KEYWORD
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Liver cirrhosis, Collagen accumulation, Bile duct ligation
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