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KMID : 1200820020020020106
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Oriental Pharmacy and Experimental Medicine
2002 Volume.2 No. 2 p.106 ~ p.112
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Magnoliae Cortex inhibits immediate-type allergic reactions
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Shin Tae-Yong
Oh Ro-Sa
Lee Eon-Jeong
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Abstract
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The effect of aqueous extract of Magnoliae Cortex (Magnoliaceae) (MCAE) on the immediate-type allergic reaction was investigated. MCAE inhibited compound 48/80 induced systemic anaphylactic reaction in rats. MCAE (0.1 and 1 g/kg) also significantly inhibited local immunoglobulin E (lgE)-mediated passive cutaneous anaphylactic (PCA) reaction. MCAE (0.001 to 1 mg/ml) dose-dependently inhibited the histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-dinitrophenyl (DNP) 1gE. Moreover, MCAE (0.01 to 1 mg/ml) had a significant inhibitory effect on anti-DNP IgE-mediated tumor necrosis production. These results indicate that MCAE inhibits immediate-type allergic reaction in vivo and in vitro.
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KEYWORD
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Magnoliae Cortex, Immediate-type allergic reaction, Compound 48/80, Anti-DNP IgE, Histamine, Tumor necrosis
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