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KMID : 1200820030030010021
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Oriental Pharmacy and Experimental Medicine
2003 Volume.3 No. 1 p.21 ~ p.28
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Pharmacological study of ’treenoponchomul’-an Ayurvedic diuretic preparation
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Haque Sabera
Hannan JMA
Shahriar Masum
Islam M Naimul
Sattar Mafruhi
Choudhuri MSK
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Abstract
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The pharmacological effects of an Ayurvedic diuretic drug ’Treenoponchomul’ (TPM) was investigated in animal model. The pharmacological actions of the test drug along with that of the components thereof, on the Central Nervous System (CNS) were studied. The drug under study TPM showed little effect on the CNS, the same can not be said about the components. The most prominent CNS depressant effect was observed with Saccharum officinarum Linn. (EE) in that it lowered the spontaneous motor activity as well the exploratory -behavior of the animals. An exploration retarding effect of moderate degree, was evident with Imperata cylindrica Beauv. (UU), and Phragmites maxima Blatter & McCann (NN). Although the test drug did not alter the normal locomotor and/ or exploratory behavior of the treated animals, it did significantly (p<0.01) lower the locomotion of the amphetamine induced hyperactive animals. TPM along with its components (especially Desmostachya bipinnata Stapf. Root, KU), significantly reduced the gastro-intestinal motility of the treated animals (p<0.01). The test drug and its components lowered the body weight of the treated animals, on being administered chronically (30 days), with EE being the only exception.
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KEYWORD
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Treenoponchomul, Diuretic, Saccharum officinarum, Saccharum spontaneum, Desmostachya bipinnata, Phragmites maxima, Imperata cylindrica
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