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KMID : 1200820030030010034
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Oriental Pharmacy and Experimental Medicine
2003 Volume.3 No. 1 p.34 ~ p.39
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Immune-enhancement effect of JaSaengHwan
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Shin Hye-Young
Koo Hyun-Na
Hong Seung-Heon
An Hyo-Jin
Kim Hyung-Min
Shin Tae-Yong
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Abstract
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We investigated the immune enhancement effects of JaSaengHwan (JSH). The forced swimming test (FST) has been used as a screening model for new immune enhancement agents. We found that JSH (0.1 mg/ml) significantly reduced the immobility time in the FST compared to the control. Also, we investigated the effect of JSH on the proliferation of T cell and production of cytokines in human T-cell line, MOLT-4 cells and mouse peritoneal macrophages. JSH (1 mg/ml) significantly increased the cell proliferation by (p<0.05) and also significantly increased the interleukin (IL)-2, IL-4 and interferon production compared with media control (about 2-fold for IL-2, 3-fold for IL-4 and 1.5-fold for , p<0.05) at 24 h. In addition, JSH increased the production of IL-12 on the mouse peritoneal macrophages (by 3.6-fold for IL-12, p<0.05). In conclusion, these data indicate that JSH may have an immune-enhancement effect.
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KEYWORD
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Immune enhancement, JaSaengHwan, Forced swimming test, Proliferation, Cytokines
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