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KMID : 1200820030030020051
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Oriental Pharmacy and Experimental Medicine
2003 Volume.3 No. 2 p.51 ~ p.55
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Resibufogenin induces cardiac arrhythmia
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Xie Jing-Tian
Mehandale Sangeeta R.
Malechar Spring A.
Yuan Chun-Su
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Abstract
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Resibufogenin is a single compound isolated from the skin venom gland of the toad (Bufo bufo gargarizans cantor). Formulations containing toad venom have been widely used as complementary and alternative medicines. However, like digitalis, resibufogenin possesses both pharmacological and toxicological activities. Our previous data indicated that resibufogenin induces electro-toxicity, including delayed afterdepolarization and triggered arrhythmias at high concentration, both in cardiac fiber in vitro and in beating heart in vivo.
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KEYWORD
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Resibufogenin, Toad venom, Digitalis, Arrhythmia
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