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KMID : 1200820030030020056
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Oriental Pharmacy and Experimental Medicine
2003 Volume.3 No. 2 p.56 ~ p.62
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Effect of Terminalia chebula fruit on anaphylaxis by anal therapy
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Shin Hye-Young
Lee Kyung-Bo
Jung Yun-Hee
Kim Eun-Ah
Lee Mi-Young
Lee Mi-Ri
Kim Sang-Yong
Kim Sang-Hyun
Shin Tae-Yong
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Abstract
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The effect of aqueous extract of Terminalia chebula fruit (Combretaceae) (TCAE) by anal administration on mast cell-dependent immediate-type anaphylactic reactions was investigated. TCAE (0.005 to 1 g/kg) inhibited systemic anaphylaxis induced by compound 48/80 in mice. When TCAE was pretreated at the same concentrations with systemic anaphylaxis, the plasma histamine levels were reduced in a dose-dependent manner. TCAE (0.1 and 1 g/kg) also significantly inhibited local anaphylaxis activated by anti-DNP IgE. TCAE (0.001 to 1 mg/ml) dose-dependently inhibited the histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. Moreover, TCAE (0.01 and 0.1 mg/ml) had a significant inhibitory effect on anti-DNP IgE-mediated tumor necrosis production from RPMC. These results provide evidence that anal therapy of TCAE may be beneficial in the treatment of systemic and local mast cell-dependent anaphylaxis.
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KEYWORD
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Terminalia chebula, Anal therapy, Anaphylaxis, Compound 48/80, Anti-DNP IgE, Histamine, Tumor necrosis
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