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KMID : 1200820030030020080
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Oriental Pharmacy and Experimental Medicine
2003 Volume.3 No. 2 p.80 ~ p.83
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Inhibitory effects of ethanol extract of Atractylodis Rhizoma on melanogenesis in B16/F10 melanoma cells
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Chun Hyun-Ja
Lee Jeong-Ho
Choi Eun-Young
Baek Seung-Hwa
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Abstract
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The inhibitory effect of Atractylodis Rhizoma alba extract(AM) on melanogenesis was studied by using B16/F10 melanoma in culture. Cells were cultured in the presence of various concentrations of AM for 48 hrs, and the experiment of total melanin content as a final product and activity of tyrosinase, a key enzyme, in melanogenesis. AM significantly inhibited tyrosinase activity, and melanin content in a dose-dependent manner. These results show that Atractylodes macrocephala extract could be developed as skin whitening components of cosmetics.
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KEYWORD
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Atractylodes macrocephala(AM), Melanin biogenesis, Tyrosinase
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