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KMID : 1200820030030030129
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Oriental Pharmacy and Experimental Medicine
2003 Volume.3 No. 3 p.129 ~ p.132
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Fenugreek seed polyphenols inhibit RBC membrane activity
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Anuradha Carani V.
Kaviarasan Subramanian
Vijayalakshmi Kodali
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Abstract
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The hypoglycemic and hypolipidaemic effects of fenugreek seeds (Trigonella foenum graecum) are well established. Owing to the wide spread use of the seeds by healthy individuals and by diabetic patients we wanted to test whether the seeds can affect biological systems such as membrane transport function. In the present study fenugreek seed polyphenols were extracted and their effect on erythrocyte membrane-bound sodium-potassium adenosine triphosphatase activity was studied in vitro. Fenugreek seed polyphenols inhibited in erythrocyte membrane of diabetic and normal subjects. Maximum inhibition was observed at of extract containing 0.75 mM gallic acid equivalents. The uncoupling of membrane ATPases in vitro suggest that polyphenols from fenugreek seeds may possess a positive inotropic effect.
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KEYWORD
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Trigonella foenum graecum, RBC membrane, Diabetes
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