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KMID : 1200820030030030147
Oriental Pharmacy and Experimental Medicine
2003 Volume.3 No. 3 p.147 ~ p.150
Anti-ulcer and wound healing activity of Ruta graveolens
Somchit Nhareet

Rahman Shamima A.
Zuraini A
Abdullah Abdul Salam
Abstract
The effects of ethanol extract of Ruta graveolens on ulceration induced by ethanol and wound healing properties were investigated in mice. Oral administration of the extract reduced the incidence of ulcer, ulcer index and ulcer length produced by ethanol. The gastroprotective effects of R. graveolens were observed in a dose-dependent manner. However, this activity was statistically less potent than the anti-ulcer drug, omeprazole. When the extract applied on the wound, it promoted wound healing in mice. The wound contraction was faster in these mice when compared to untreated wounds. Based on these present findings, R. graveolens possesses anti-ulcer activity and promotes incision wound healing in mice.
KEYWORD
Ulcer, Wound healing, Ruta graveolens
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