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KMID : 1200820040040010009
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Oriental Pharmacy and Experimental Medicine
2004 Volume.4 No. 1 p.9 ~ p.17
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Effect of thymus extract on the activation of cytotoxic and accessory functions of tumor-associated macrophages
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Shrivastava Pratima
Singh Sukh Mahendra
Singh Nisha
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Abstract
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The present investigation was under taken to study whether the tumor-associated macrophages (TAM) of Daltons lymphoma (DL), a spontaneous transplantable murine T cell lymphoma can be activated to tumoricidal state by crude thymus extract. Intraperitoneal administration of thymus extract to DL-bearing mice resulted in activation of TAM with an enhanced IL-1, TNF and antigen presenting ability. It was found that treatment with thymus extract could also enhance the phagocytic and cytotoxic activity of TAM. However, only a marginal increase in arginase activity was observed. Till date to the best of our knowledge the effect of crude thymus extract on the activation of tumor associated macrophages has not been investigated, this study provides a new piece of information in the area of thymus therapy.
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KEYWORD
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Tumor-associated macrophages, Daltons lymphoma, IL-1, Antigen presentation, Cytotoxicity, Phagocytosis, Arginase activity
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