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KMID : 1200820040040010049
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Oriental Pharmacy and Experimental Medicine
2004 Volume.4 No. 1 p.49 ~ p.52
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Anticancer Properties of Total Alkaloid fraction of Solanum pseudocapsicum unripe fruits
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Badami Shrishailappa
Dhonde Satish G.
Reddy SA Manohar
P. Vijayan
B. Suresh
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Abstract
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The total alkaloid fraction of the methanolic extract of Solanum pseudocapsicum unripe fruits was tested for its in-vivo anticancer activity against Dalton’s Lymphoma Ascites model in mice. The total alkaloid fraction at 5.0 and 10.0 mg/kg body weight showed significant increase in the mean survival time and the percentage increase in the life span of tumor bearing mice. The increase in the body weight was found to be less than that of the control. However, the treatment at 20 mg/ kg body weight was found to be toxic and showed a decrease in the mean survival time, and body weight when compared to control mice. The antitumor activity observed may be due to the cytotoxic activity of the total alkaloid fraction.
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KEYWORD
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Antitumor, Dalton Lymphoma Ascites, Solanum pseudocapsicum, Total alkaloid fraction
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