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KMID : 1200820040040020077
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Oriental Pharmacy and Experimental Medicine
2004 Volume.4 No. 2 p.77 ~ p.81
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Effect of Crotalaria juncea seed extracts on the estrous cycle and ovarian activity in albino mice
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Malashetty Vijaykumar B.
I. Sangamma
A. Sharanabasappa
Patil Saraswati B.
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Abstract
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Petroleum ether, benzene and alcohol extracts of seeds of C. juncea administered orally at the dose level of 25mg/100g body weight to adult female mice for 30 days, resulted in irregular estrous cycle with prolonged estrus and metaestrus and reduced diestrus and proestrus during the experimental period. Histological studies of the ovary indicate increases in the number of atretic follicles but decreases in the number of developing follicles, Graafian follicles and corpora lutea. The total cholesterol content of the ovary is increased, whereas ascorbic acid content is decreased. The weight of the uterus and its micrometric measurement in all experimental mice are increased significantly. The alcoholic extracts showed estrogenic activity in immature mice by early opening of the vagina, premature cornification of the vaginal epithilium and increases in uterine weight. However, alcohol extract of seeds of C. juncea was more effective in causing these changes compared to other extracts. After subjecting to preliminary phytochemical screenings alcohol extract showed positive; test for alkaloids, steroids, glycosides, flavones, phenols and tannins.
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KEYWORD
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Crotalaria juncea, Mice, Estrous cycle, Ovary, Estrogenic activity
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