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KMID : 1200820040040030157
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Oriental Pharmacy and Experimental Medicine
2004 Volume.4 No. 3 p.157 ~ p.161
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Traditional oriental herbal medicine, Jukyeoondam-tang, occludes aconitine-induced ventricular arrhythmia in hearts
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Ha Ki-Chan
Chae Han-Jung
Piao Cheng-Shil
Chae Soo-Uk
Kim Hyung-Ryong
Chae Soo-Wan
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Abstract
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We showed the effects of the traditional herbal medicine, Jukyeoondam-tang (JO-T, Zhu-ru-Wen-Dan-Tang in Chinese), on ventricular arrhythmia induced by aconitine. Electrophysiological experiments with conventional microelectrode techniques revealed that JO-T potently suppressed the aconitine-induced arrhythmias in ventricular strips of the rat. In the aconitine-induced arrhythmia model of the rat, pretreatment with JO-T completely occluded the appearance of ventricular tachyarrhythmia (VT) or ventricular fibrillation (VF) induced by aconitine. Furthermore, the aconitine-induced ventricular arrhythmia was occluded by channel blocker quinidine but was not occluded by channel blocker glibenclamide channel blocker nifedipine . We also confirmed the effect of JO-T in the ischemia-reperfusion (I/R)-induced arrhythmia model of the rat. JO-T did not affect the I/R-induced arrhythmias in rats. JO-T may alleviate the risk of ventricular arrhythmias following aconitine. These results suggest that JO-T is a potent antiarrhythmic drug having a channel-blocking action.
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KEYWORD
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Jukyeoondam-tang (JO-T, 竹茹溫膽湯, Zhu-ru-Wen-Dan-Tang), Aconitine, Arrhythmia, channel, Ischemia-reperfusion (I/R)
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