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KMID : 1200820040040030163
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Oriental Pharmacy and Experimental Medicine
2004 Volume.4 No. 3 p.163 ~ p.170
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Immune activation and radioprotection by Echinacea purpurea (American herb)
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Mishima Satoshi
Gu Yeun-Hwa
Saito Kiyoto
Yamashita Takenori
Maruyama Hiroe
Inoue Makoto
Ahn Kyoo-Seok
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Abstract
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The effect of immune activation by Echinacea purpurea was investigated by measuring total immunoglobulin (Ig) G, IgM. and the radioprotective effect of immune activation by Echinacea purpurea was investigated by measuring T lymphocyte subsets in the peripheral blood of mice following whole body irradiation. Echinacea purpurea activated macrophages to stimulate production in association with the secondary activation of T lymphocytes, resulting in a decrease in IgG and IgM production. Cytokines released from macrophages in mouse peripheral blood after Echinacea purpurea administration activated helper T cells to proliferate. In addition, activated macrophages in association with the secondary T lymphocyte activation increased production and stimulated proliferation of cytotoxic T cells and suppressor T cells, indicating the activation of cell-mediated immune responses.
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KEYWORD
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Echinacea purpure, Immunology, Radiation protection, T lymphocyte
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