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KMID : 1200820040040030179
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Oriental Pharmacy and Experimental Medicine
2004 Volume.4 No. 3 p.179 ~ p.185
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Biological activity of an Indian medical plant, Indigofera cordifolia
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Rao Bhattiproulu Kesava
Kawase Masami
Tanaka Toru
Tani Satoru
Motohashi Noboru
Satoh Kazue
Sakagami Hiroshi
Terakubo Shigemi
Nakashima Hideki
Wolfard Krisztina
Molnar Joseph
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Abstract
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The ethanol extract of Indigofera cordifolia was studied for in vivo gastroprotective activity, cytotoxic activity against oral tumor and normal cells, multidrug resistance (MDR) reversal activity, anti-human immunodeficiency virus (HIV) activity and radical scavenging activity. The extract of I. cordifolia showed potent gastric mucosal protective activity against stomach injury induced by HCl/EtOH solution. However, the gastroprotective activity could not be related to the radical mechanism, because the extract weakly scavenged both OH radical and . The extract also showed promising levels of MDR-reversing activity. This study demonstrates the tumor-specific cytotoxic action of the plant extract. However, the extract had no anti-HIV activity. From above results, the study suggests the medicinal importance of I. cordiforia extract.
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KEYWORD
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Indigofera cordifolia, Gastroprotective activity, Cytotoxic activity, MDR, Anti-HIV, Radical intensity
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