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KMID : 1200820040040030211
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Oriental Pharmacy and Experimental Medicine
2004 Volume.4 No. 3 p.211 ~ p.214
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Inhibitory effects of dl-Puerol A in the root of Sophora japonica on copper ion-induced protein oxidative modification of mouse brain homogenate in vitro
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Toda Shizuo
Shirataki Yoshiaki
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Abstract
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The inhibitory effect of dl-puerol A as but-2-enolide isolated from Sophora japonica was investigated on copper ion-induced protein oxidative modification in vitro. It inhibited copper-induced protein oxidative modification. However, its inhibitory effect was a little weaker than that of as an antioxidant. The results demonstrated that dl-puerol A, one of but-2-enolides, might be of use in the oxidative stress.
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KEYWORD
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Copper, Protein oxidative modification, dl-puerol A, Sophora japonica
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