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KMID : 1200820040040040243
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Oriental Pharmacy and Experimental Medicine
2004 Volume.4 No. 4 p.243 ~ p.247
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A protective effect of the methanol extract of Shelliguea feei METT. roots on gastric ulcers in mice and rats
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Subarnas Anas
Herdiana Yana
Sriwidodo Sriwidodo
Dianti Ajeng
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Abstract
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A protective effect of the methanol extract of Shelliguea feei METT. roots on gastric lesions induced by stress in mice and HCl/ethanol in rats has been investigated. Animals were randomly divided into control and test groups and given the methanol extract orally at doses of 0.5, 1.0, and 2.0 g/kg of body weight. This investigation indicated that the methanol extract at doses of 1.0 and 2.0 g/kg significantly reduced stress-induced gastric lesions in mice at the percent protection of 38% and 62%, respectively, and decreased the number of HCI/ethanol-induced ulcers in rats significantly at the percent inhibition of 21.50% and 90.65%, respectively, and severity of ulcers at the score of 3.6 and 1.0 significantly different from the control. These results suggest that the methanol extract of S. feei may have a beneficial protective effect on the gastric ulcers.
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KEYWORD
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Shelliguea feei, Ulcer, Anti-ulcerogenik, Shelegueain A
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