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KMID : 1200820040040040249
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Oriental Pharmacy and Experimental Medicine
2004 Volume.4 No. 4 p.249 ~ p.252
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Central nervous system depressant activity of Diospyros peregrina bark
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Shilpi Jamil Ahmad
Uddin Shaikh Jamal
Rouf Razina
Billah Md. Morsaline
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Abstract
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The methanol extract of Diospyros peregrina bark was studied for its effect on the central nervous system (CNS) using the pentobarbitone induced sleeping time test, the open field test and the hole cross test in Swiss albino mice. The present investigation revealed that the extract, at the doses of 250 and 500 mg/kg, significantly prolonged the pentobarbitone induced sleeping time in mice though the onset of sleep was delayed as compared to the control. In open field test, the depressing effect was prominent from the second observation period (30 min) and persisted throughout the entire experimental period (240 min). In the hole cross test, the depressing effect was observed from the second observation period (30 min) and persisted up to fifth observation period (120 min) for 250 mg dose group and up to sixth observation period (180 min) for 500 mg dose group. These results support the finding that D. peregrina bark extract at the above doses has CNS depressing effects and indicate that D. peregrina bark may contain biologically active constituent(s) having CNS depressant activity.
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KEYWORD
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Diospyros peregrina, Central nervous system, Pentobarbitone induced sleeping time, Open field test, Hole cross test
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