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KMID : 1200820050050010001
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Oriental Pharmacy and Experimental Medicine
2005 Volume.5 No. 1 p.1 ~ p.15
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The anti-hyperglycemic property of different ginseng partitions
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Xie Jing-Tian
Wang Chong-Zhi
Kim Stephen
Yuan Chun-Su
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Abstract
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Ginseng is a popular medicinal plant highly valued throughout the world. Asian ginseng is one of the most common species of ginseng. It has long occupied a significant position in oriental medicine and has been justified its name as the ’king herb’. As a nutritional supplement, ginseng is an extremely common and popular herbal medicine in the United States and Canada in recent decades. The multiple constituents of ginseng possess equally multifaceted pharmacological actions as demonstrated by numerous studies. Ginseng root and its constituents influenced the central nervous system, endocrine, cardiovascular, gastrointestinal system, sexual, renal organ and immune system, etc. One important action is its anti-hyperglycemic effect. Previous studies on ginseng demonstrate that only the root of ginseng has been used in the treatment of diabetes, while the other parts of ginseng plant were always neglected. Recently, we analyzed the constituents of ginseng berry, leaf and discovered that ginseng berry, leaf extracts and its total ginsenosides have the ability to reduce hyperglycemia and body weight and increase the peripheral glucose utilization in obese or diabetic ob/ob or db/db mice. Our data suggest that all parts of ginseng plant, including root, berry, leaf and stem exhibit potent anti-hyperglycemic and anti-obese effects and may provide an opportunity to develop a novel class of anti-diabetic agents.
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KEYWORD
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Ginseng, Anti-hyperglycemic effect, Anti-obese effect, Ginseng root, Berry, Leaf, ob/ob and db/db mice
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