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KMID : 1200820050050010016
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Oriental Pharmacy and Experimental Medicine
2005 Volume.5 No. 1 p.16 ~ p.20
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Antioxidant activity of Grewia tiliaefolia bark
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Badami Shrishailappa
Gupta Mahesh Kumar
M. Ramanathan
B. Suresh
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Abstract
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Grewia tiliaefolia is commonly used in India and several other countries for its ethnomedical properties. The antioxidant effect of 50% methanol extract of Grewia tiliaefolia bark was investigated by in-vitro and in-vivo methods. The extract exhibited value of in DPPH assay. In the in vivo experiments, the treatment was given at 250 and 500 mg/kg body weight doses orally for seven days and catalase, SOD, TBA-RS and ascorbic acid levels were estimated. Both the doses caused a significant increase in the levels of catalase in the liver and kidney, and SOD in the liver, kidney and blood serum. A significant decrease in the level of TBARS was also observed. These results suggest potent antioxidant nature of the extract.
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KEYWORD
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Grewia tiliaefolia, Tiliaceae, Antioxidant, Free radical scavengers, Lipid peroxidation
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