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KMID : 1200820050050010069
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Oriental Pharmacy and Experimental Medicine
2005 Volume.5 No. 1 p.69 ~ p.74
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Effect of Korean folk medicine ’SecSec’ on inflammatory cytokine secretion in HMC-1 cells
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Choi In-Young
Kim Mi-Sun
Koo Hyoun-Na
Hong Seung-Hun
Kim Hyung-Min
Um Jae-Young
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Abstract
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’SecSec’ has been used for the purpose of prevention and treatment of throat diseases such as sore throat, cough, bronchial asthma and allergic asthma in Korea. However, its effect in experimental models remains unknown. To investigate the biological effect of SecSec, we examined cytotoxicity and secretion of inflammatory cytokines on human leukemic mast cell line, HMC-1, stimulated with phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187. SecSec by itself had no cytotoxicity on HMC-1. When SecSec (1 mg/ml) was added, the secretion of tumor necrosis factor-alpha , interleukin (IL)-6, and granulocyte macrophage-colony stimulating factor (GM-CSF) was significantly inhibited about 47.20%, 25.55%, and 46.43%, respectively on PMA plus A23187-stimulated HMC-1 cells. But SecSec did not inhibit IL-8 secretion. These findings may help understanding the mechanism of action of this medicine leading to control activated mast cells on allergic inflammatory condition like asthma.
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KEYWORD
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Asthma, Human mast cell line HMC-1, GM-CSF, IL-6, IL-8
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