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KMID : 1200820050050020124
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Oriental Pharmacy and Experimental Medicine
2005 Volume.5 No. 2 p.124 ~ p.136
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Analgesic and antiinflammatory activity of Alstonia macrophylla and Mallotus peltatus leaf extracts: Two popular ethnomedicines of Onge, a Negrito tribe of little Andaman
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Chattopadhyay Debprasad
Arunachalam G
Sur Tapas Kumar
Bhattacharya SK
Mandal Asit Baran
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Abstract
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Two popular ethnomedicines of the Onge, a Negrito tribe of Andaman Islands, were evaluated for analgesic and antiinflammatory activity. The methanol extract as well as the different fractions of methanol extract of both Alstonia macrophylla and Mallotus peltatus leaves were studied using Swiss albino mice and Wistar albino rats. Acetic acid induced writhing, Tail flick and Tail immersion; Carrageenin- and Dextran-induced paw oedema tests were used. Dose-dependent analgesic and antiinflammatory activity were demonstrated for both methanol leaf extracts as well as fractions. Results were highly comparable with that of the standard drug pethidine.
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KEYWORD
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Alstonia macrophylla, Mallotus peltatus, Triterpenoids, Sterols, Analgesic activity, Antiinflammatory activity
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