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KMID : 1200820050050020156
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Oriental Pharmacy and Experimental Medicine
2005 Volume.5 No. 2 p.156 ~ p.159
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Experimental research for the protective effect of Naoxingtong-containing serum on rat cerebral microvascular endothelial cells
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Zhou Jun
Guo Jianyou
Guo Jian
Li Lanfang
Li Canghai
Jiang Nan
Guo Shuying
Huo Hairu
JiangTingliang
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Abstract
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The protective effect of Naoxingtong (NXT) on rat cerebral microvascular endothelial cell (rCMEC) was investigated. rCMEC was injured in vitro by incubating for 4 hours at 100% NO in a hypoxia chamber. After treated with NXT-containing serum, the cellular viability rate (90.3%) was significantly elevated when compared with that of control group and the inhibitive rate of lactic dehydrogenase activity (9.2%) was far lower than the control group with dose-dependent effect. The results indicate that NXT can increase viability of rCMEC, and protect cell membrane from injury during hypoxia.
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KEYWORD
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NXT, Drug-containing serum, CMEC, Lactic dehydrogenase
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