|
KMID : 1200820050050030236
|
|
Oriental Pharmacy and Experimental Medicine
2005 Volume.5 No. 3 p.236 ~ p.239
|
|
|
Effects of Naoxintong-containing serum on NO and CGRP in rat cerebral microvascular endothelial cells
|
|
Li Lanfang
Li Canghai
Haixia Dang
Jiang Nan
Guo Jianyou
Guo Shuying
Huo Hairu
JiangTingliang
|
|
|
Abstract
|
|
|
|
Effects of Naoxintong (NXT, a formula of Chinese Materia Medica)-containing serum on Nitrogen monoxide (NO) and calcitonin gene related peptide (CGRP) in rat cerebral microvascular endothelial cells (rCMEC) was investigated, rCMEC was injured in vitro by incubating for 4 hours at 100% NO in a hypoxia chamber. The results indicated that NXT could antagonize the reduction of NO and CGRP secreted by rCMEC during hypoxia, the effect of which was dose-dependent. After treated with NXT-containing serum at dosage of 5.0 - 30 and 50 -1.1 g/kg/U respectively, the amount of NO and CGRP secreted by rCMEC were remarkably increased during hypoxia in vitro.
|
|
|
KEYWORD
|
|
|
Naoxintong, Drug-containing serum, Cerebral microvascular endothelial cell, Nitrogen monoxide, Calcitonin gene related peptide
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|