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KMID : 1200820050050030240
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Oriental Pharmacy and Experimental Medicine
2005 Volume.5 No. 3 p.240 ~ p.245
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Antifilarial activity of Nigella sativa on Setaria cervi-an in vitro study
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Rizvi Waseem
Kumar Anil
Rizvi NH
Ahmad Razi
Singhal KC.
Khan Atif
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Abstract
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The effect of aqueous and alcoholic extract of seeds of Nigella sativa (N. sativa) was studied on the spontaneous movements of the whole worm (w.w) preparation and nerve muscle (n.m) complex of Setaria cervi (S. cervi). Both the extracts caused inhibition of spontaneous movements of the w.w and n.m complex characterized by initial stimulation followed by irreversible paralysis, with the exception that aqueous extract produced a partially reversible paralysis of w.w preparation. Lesser concentration of both the extracts was required to inhibit the movements of n.m complex than the w.w. Suggesting a cuticular permeability barrier. The lethal concentration and lethal concentration were 30 and 55 ng/ml for aqueous and 45 and 60 ng/ml for alcoholic extracts respectively.
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KEYWORD
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Nigella sativa, Antifilarial, Setaria cervi
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